methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate

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Chemical Name:methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate
CAS No.:945860-97-9
Molecular Formula:C₂₅H₂₄F₃N₃O₄S
Molecular Weight:519.544
Hs Code.:

Synonyms:methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate

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Chemical Property of methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate

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Technology Process of methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate

There total 1 articles about methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 945860-78-6
methyl 2-(1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate

: 105512-79-6
4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine

: 945860-97-9
methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate

Guidance literature:: bis(trichloromethyl) carbonate; 4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

methyl 2-(1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 92.0%

: 945860-97-9
methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate

: 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoic acid

Guidance literature:: methyl 2-(2-(4-(4-(trifluoromethyl)phenyl)thiazol-2-ylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-6-yloxy)-2-methylpropanoate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; water; In tetrahydrofuran;