1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea

Base Information

Chemical Name:1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea
CAS No.:1402581-93-4
Molecular Formula:C₂₃H₂₂F₃N₅O₂
Molecular Weight:457.455
Hs Code.:

Synonyms:1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea

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Chemical Property of 1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea

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Technology Process of 1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea

There total 10 articles about 1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1255041-94-1
(1-(3-chlorophenyl)-3-cyclopropyl-1H-pyrazol-5-yl)methanamine monohydrochloride

: 1402586-31-5
phenyl 3-fluoro-4-(3-hydroxyazetidin-1-yl)phenylcarbamate

: 1402581-93-4
1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea

Guidance literature:: With triethylamine; In acetonitrile; for 16h; Reflux;

Reference yield:

: 765-43-5
Cyclopropyl methyl ketone

: 1402581-93-4
1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium ethanolate / ethanol / 3 h / 0 - 20 °C

2.1: ethanol; water / 1 h / 20 °C

3.1: acetic acid / 2-methoxy-ethanol / 3 h / 105 °C

4.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 0 - 20 °C

5.1: pyridine; di-tert-butyl dicarbonate / 1,4-dioxane / 0.5 h / 0 °C

5.2: 0 - 20 °C

6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 0 - 70 °C

6.2: 0 °C / pH Ca_. 4

7.1: triethylamine / acetonitrile / 16 h / Reflux

With pyridine; di-tert-butyl dicarbonate; dimethylsulfide borane complex; water; sodium ethanolate; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; 2-methoxy-ethanol; water; acetonitrile;

Reference yield:

: 21080-80-8
ethyl 4-cyclopropyl-2,4-dioxobutanoate

: 1402581-93-4
1-((3-cyclopropyl-1-(3,4-difluorophenyl)-1H-pyrazol-5-yl)methyl)-3-(3-fluoro-4-(3-hydroxyazetidin-1-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol; water / 1 h / 20 °C

2.1: acetic acid / 2-methoxy-ethanol / 3 h / 105 °C

3.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 0 - 20 °C

4.1: pyridine; di-tert-butyl dicarbonate / 1,4-dioxane / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 0 - 70 °C

5.2: 0 °C / pH Ca_. 4

6.1: triethylamine / acetonitrile / 16 h / Reflux

With pyridine; di-tert-butyl dicarbonate; dimethylsulfide borane complex; water; acetic acid; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; 2-methoxy-ethanol; water; acetonitrile;