Technology Process of 1,4-diferrocenyl-4-methoxy-1,4-diphenylbut-2-ynol
There total 1 articles about 1,4-diferrocenyl-4-methoxy-1,4-diphenylbut-2-ynol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran;
n-BuLi soln. was added at -60°C under Ar to a THF soln. of the propyne, the stirred was allowed to warm to room temp., FcCOPh was added under Ar, the mixt. was stirred for 18 h; water was added, solvents were removed in vacuo, the residue was dissolved in ether, soln. washed with water, dried over Na2SO4, evapd., residuewas chromd. on basic alumina (eluent 2:1 hexane-ether); elem. anal.;
- Guidance literature:
-
With
tin(ll) chloride;
In
methanol; acetic acid;
a soln. of SnCl2 in aq. 50% AcOH was added under Ar to a stirred suspn. of the butynol in MeOH, the mixt. was refluxed for 30 min; 1:1 mixt. of cis and trans isomers was formed; cooled to room temp., water added, extd. with CH2Cl2, org. phase was washed with water, dried over Na2SO4, evapd., residue was chromd. on basic alumina with 5:1 hexane-ether; elem. anal.;
- Guidance literature:
-
With
aluminium trichloride; titanium(III) chloride; lithium;
In
1,2-dimethoxyethane;
Sonication; a mixt. of TiCl3*AlCl3 and Li powder in DME was sonicated under Ar in anultrasonic cleaning bath for 30 min, the butynol was added, solication was continued for 1 h; an 1:1 mixt. of isomers was obtained; the mixt. was poured onto ice/water, extd. with Et2O, org. layer was dried with Na2SO4 and evapd.; elem. anal.;
