N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

Base Information

Chemical Name:N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide
CAS No.:1415836-51-9
Molecular Formula:C₂₁H₂₅N₃O₃S
Molecular Weight:399.514
Hs Code.:

Synonyms:N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

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Chemical Property of N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

Chemical Property:

Purity/Quality:

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Technology Process of N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

There total 5 articles about N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415836-50-8
4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

: 1415836-51-9
N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 179557-01-8
4-cyclopropylamino-piperidine-1-carboxylic acid tert-butyl ester

: 1415836-51-9
N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

1.2: 20 °C

2.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 6 h / 90 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 6311-35-9
6-bromonicotinic acid

: 1415836-51-9
N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / Cooling with ice

1.2: 20 °C

2.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 6 h / 90 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;