4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester

Base Information

Chemical Name:4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester
CAS No.:1557031-11-4
Molecular Formula:C₂₅H₃₁N₃O₅S
Molecular Weight:485.604
Hs Code.:

Synonyms:4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester

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Chemical Property of 4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester

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Technology Process of 4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester

There total 5 articles about 4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415836-51-9
N-cyclopropyl-6-(4-methanesulfonyl-phenyl)-N-piperidine-4-yl-nicotinamide

: 108-23-6
isopropyl chloroformate

: 1557031-11-4
4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: 1415836-49-5
4-[(6-bromo-pyridine-3-carbonyl)-cyclopropyl-amino]-piperidine-1-carboxylic acid tert-butyl ester

: 1557031-11-4
4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide; water / 0.17 h / Inert atmosphere

1.2: 6 h / 90 °C

2.1: trifluoroacetic acid / dichloromethane

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1415836-50-8
4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

: 1557031-11-4
4-{cyclopropyl-[6-(4-methanesulfonyl-phenyl)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;