di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

Base Information

Chemical Name:di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate
CAS No.:1349734-22-0
Molecular Formula:C₃₈H₄₆N₈O₉
Molecular Weight:758.831
Hs Code.:

di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

Synonyms:di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

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Chemical Property of di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

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Technology Process of di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

There total 7 articles about di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1349734-07-1
2-(2-oxo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-1(2H)-yl)propanenitrile

: 1349734-21-9
tert-butyl N-[[4-[5-[3-[bis(tert-butoxycarbonyl)amino]-6-bromopyrazin-2-yl]-1,3,4-oxadiazol-2-yl]-3-methoxyphenyl]methyl]-N-methylcarbamate

: 1349734-22-0
di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; acetonitrile; at 85 ℃; for 1h;

Reference yield:

: 1225062-23-6
3-amino-6-bromopyrazine-2-carbohydrazide

: 1349734-22-0
di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibromotriphenylphosphorane / acetonitrile / 2 h / 20 °C

1.2: Cooling with ice

1.3: 0.33 h

2.1: sodium carbonate / tetrahydrofuran; methanol / 1.67 h / 60 °C

3.1: dmap / tetrahydrofuran / 16.5 h / 20 - 45 °C

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 85 °C

With dmap; sodium carbonate; dibromotriphenylphosphorane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; water; acetonitrile;

Reference yield:

: 88709-30-2
4-(bromomethyl)-2-methoxybenzoic acid

: 1349734-22-0
di-tert-butyl 3-(5-(4-((tert-butoxycarbonyl(methyl)amino)methyl)-2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-5-(1-(1-cyanoethyl)-6-oxo-1,6-dihydropyridin-3-yl)pyrazin-2-yliminodicarbonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibromotriphenylphosphorane / acetonitrile / 2 h / 20 °C

1.2: Cooling with ice

1.3: 0.33 h

2.1: sodium carbonate / tetrahydrofuran; methanol / 1.67 h / 60 °C

3.1: dmap / tetrahydrofuran / 16.5 h / 20 - 45 °C

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile; water / 1 h / 85 °C

With dmap; sodium carbonate; dibromotriphenylphosphorane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; water; acetonitrile;