(R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide

Base Information

Chemical Name:(R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide
CAS No.:1312764-82-1
Molecular Formula:C₁₇H₂₃NO₄S₂
Molecular Weight:369.506
Hs Code.:

Synonyms:(R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide

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Technology Process of (R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide

There total 4 articles about (R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1312764-77-4
1-(3-amino-4-(tert-butyldimethylsilyloxy)-5-methoxyphenyl)ethanone

: 1200-22-2
(R)-1,2-dithiolane-3-pentanoic acid

: 1312764-82-1
(R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide

Guidance literature:: (R)-1,2-dithiolane-3-pentanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-(3-amino-4-(tert-butyldimethylsilyloxy)-5-methoxyphenyl)ethanone; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.ejmech.2011.03.056

Reference yield:

: 740841-82-1
1-(3-amino-4-hydroxy-5-methoxyphenyl)ethanone

: 1312764-82-1
(R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 20 h / 20 °C

2.3: 1 h / 20 °C

With 1H-imidazole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.03.056

Reference yield:

: 20716-41-0
1-(4-hydroxy-3-methoxy-5-nitrophenyl)ethan-1-one

: 1312764-82-1
(R)-N-(5-acetyl-2-hydroxy-3-methoxyphenyl)-5-(1,2-dithiolan-3-yl)pentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol

2.1: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 h / 20 °C

3.3: 1 h / 20 °C

With 1H-imidazole; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.03.056