2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

• Chemical Name: 2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS No.: 95204-59-4
• Molecular Formula: C₁₆H₁₈N₂O₆
• Molecular Weight: 334.329
• Mol file: 95204-59-4.mol

Synonyms:2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property of 2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 1 articles about 2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-(Acetyl-benzyloxy-amino)-propionic acid → 2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester (95204-59-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; 1) 0 deg C, 1 h, 2) refrigerator, 24 h;

DOI:10.1246/bcsj.57.2456

Reference yield:

2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester (95204-59-4) → 2-({2-[2-(Acetyl-hydroxy-amino)-propionylamino]-acetyl}-hydroxy-amino)-N-({hydroxy-[1-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-carbamoyl}-methyl)-propionamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1) (C₂H₅)3N / 1) THF, 0 deg C, 1 h, 2) THF, 25 deg C, 48 h

2: 95 percent / H₂ / 10percent Pd/C / methanol / 72 h / 30 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1246/bcsj.57.2456

Reference yield:

2-(Acetyl-benzyloxy-amino)-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester (95204-59-4) + 2-[(2-{2-[(2-Amino-acetyl)-benzyloxy-amino]-propionylamino}-acetyl)-benzyloxy-amino]-N-phenylcarbamoylmethyl-propionamide; hydrochloride → 2-({2-[2-(Acetyl-benzyloxy-amino)-propionylamino]-acetyl}-benzyloxy-amino)-N-({benzyloxy-[1-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-carbamoyl}-methyl)-propionamide (95204-85-6)

Guidance literature:

With triethylamine; Yield given. Multistep reaction; 1) THF, 0 deg C, 1 h, 2) THF, 25 deg C, 48 h;

DOI:10.1246/bcsj.57.2456

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Downstream raw materials:

2-({2-[2-(Acetyl-benzyloxy-amino)-propionylamino]-acetyl}-benzyloxy-amino)-N-({benzyloxy-[1-(phenylcarbamoylmethyl-carbamoyl)-ethyl]-carbamoyl}-methyl)-propionamide