C₁₇H₁₉F₅O

Base Information

• Chemical Name: C₁₇H₁₉F₅O
• CAS No.: 1016231-13-2
• Molecular Formula: C₁₇H₁₉F₅O
• Molecular Weight: 334.329
• Mol file: 1016231-13-2.mol

Synonyms:C₁₇H₁₉F₅O

Chemical Property of C₁₇H₁₉F₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₉F₅O

There total 2 articles about C₁₇H₁₉F₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Trifluoromethylbenzaldehyde (455-19-6) + 1-bromo-1,1-difluoronon-2-yne (313468-94-9) → C17H19F5O (1016231-13-2)

Guidance literature:

With indium; europium(III) trifluoromethanesulfonate; In tetrahydrofuran; water; at 40 ℃; for 12h; Sonication;

DOI:10.1039/c6cc01318j

Reference yield:

n-octyne (629-05-0) → C17H19F5O (1016231-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78.8 °C / Inert atmosphere

1.2: 16 h / -100 - 20 °C

2.1: indium; europium(III) trifluoromethanesulfonate / tetrahydrofuran; water / 12 h / 40 °C / Sonication

With indium; n-butyllithium; europium(III) trifluoromethanesulfonate; In tetrahydrofuran; hexane; water;

DOI:10.1039/c6cc01318j

Reference yield: 97.0%

C17H19F5O (1016231-13-2) → (Z)-2,2-difluoro-1-(4-(trifluoromethyl)phenyl)dec-3-en-1-ol

Guidance literature:

With ammonium formate; In water; N,N-dimethyl-formamide; at 80 ℃; for 7h; diastereoselective reaction; Green chemistry;

DOI:10.1039/c6cc01318j

upstream raw materials:

4-Trifluoromethylbenzaldehyde

1-bromo-1,1-difluoronon-2-yne

n-octyne

Downstream raw materials:

C₁₇H₁₇F₄IO

Refernces