Methotrexate Sodium

Base Information

Chemical Name:Methotrexate Sodium
CAS No.:7413-34-5
Molecular Formula:C20H20N8Na2O5
Molecular Weight:498.409
Hs Code.:2933990090
European Community (EC) Number:231-022-0,239-495-5
UNII:3IG1E710ZN
ChEMBL ID:CHEMBL3244648
DSSTox Substance ID:DTXSID3037123
NCI Thesaurus Code:C1735
Nikkaji Number:J122.426C
RXCUI:287734
Wikidata:Q27122181
Mol file:7413-34-5.mol

Synonyms:Amethopterin;Dicesium Salt Methotrexate;Hydrate, Methotrexate;Methotrexate;Methotrexate Hydrate;Methotrexate Sodium;Methotrexate, (D)-Isomer;Methotrexate, (DL)-Isomer;Methotrexate, Dicesium Salt;Methotrexate, Disodium Salt;Methotrexate, Sodium Salt;Mexate;Sodium, Methotrexate

Suppliers and Price of Methotrexate Sodium

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MethotrexateDisodiumSalt
25mg
$ 50.00

TRC
MethotrexateDisodiumSalt
50mg
$ 70.00

DC Chemicals
Methotrexatedisodium >98%
1 g
$ 300.00

Crysdot
Methotrexatedisodiumsalt 97%
25g
$ 480.00

ChemScene
Methotrexatedisodium 98.26%
100mg
$ 60.00

ChemScene
Methotrexatedisodium 98.26%
500mg
$ 156.00

Chemenu
Methotrexatedisodiumsalt 97%
25g
$ 449.00

American Custom Chemicals Corporation
METHOTREXATE DISODIUM SALT 95.00%
1G
$ 1024.78

Ambeed
Sodium(S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate 98+%
5g
$ 14.00

Alfa Aesar
Methotrexate disodium salt, 98.5%
250mg
$ 170.00

Total 114 raw suppliers

Chemical Property of Methotrexate Sodium

Chemical Property:

Boiling Point:823℃
PSA：216.20000
LogP:-0.84770
Storage Temp.:0-6°C
Sensitive.:Hygroscopic
Water Solubility.:Soluble in water
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:7
Exact Mass:498.13520433
Heavy Atom Count:35
Complexity:693

Purity/Quality:

99% ^*data from raw suppliers

MethotrexateDisodiumSalt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
Isomeric SMILES:CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
Recent ClinicalTrials:Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia
Recent EU Clinical Trials:Age-adjusted high-dose chemotherapy followed by autologous stem cell transplantation or conventional chemotherapy with R-MP as first-line treatment in elderly primary CNS lymphoma patients – a randomized phase III trial
Uses Inhibits the metabolism of folic acid

Technology Process of Methotrexate Sodium

There total 4 articles about Methotrexate Sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1379609-57-0
dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate

: 7413-34-5
disodium methotrexate

Guidance literature:: dicyanomethyl N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate; With water; potassium hydroxide; In methanol; at 20 ℃; for 0.333333h;

With hydrogenchloride; In methanol; water; pH=4.2;

With sodium hydroxide; In water; for 0.0833333h; pH=10;

Reference yield:

: 59-05-2
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

: 7413-34-5
disodium methotrexate

Guidance literature:: With sodium hydroxide; In water;
DOI:10.1039/b925831k

Reference yield:

: N-[4-(methylamino)benzoyl]-L-glutamic acid disodium

: 7413-34-5
disodium methotrexate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

2.1: water / 1 h / 58 - 62 °C / pH 2.4

3.1: potassium hydroxide; water / methanol / 0.33 h / 20 °C

3.2: pH 4.2

3.3: 0.08 h / pH 10

With water; sodium carbonate; potassium hydroxide; In methanol; water; N,N-dimethyl-formamide;