methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate

Base Information

• Chemical Name: methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate
• CAS No.: 1312356-04-9
• Molecular Formula: C₁₄H₁₄N₂O₃
• Molecular Weight: 258.277
• Mol file: 1312356-04-9.mol

Synonyms:methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate

Chemical Property of methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate

There total 2 articles about methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-{[(phenylmethyl)oxy]amino}-3-pyridinecarboxylic acid (1312356-01-6) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate (1312356-04-9)

Guidance literature:

With acetic acid; In methanol; diethyl ether; hexane; for 0.0833333h;

DOI:10.1016/j.ejmech.2014.06.061

Reference yield: 86.0%

methyl 2-fluoro-3-pyridinecarboxylate (446-26-4) + N-benzyloxyamine (622-33-3) → methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate (1312356-04-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 140 ℃; for 10h; Microwave irradiation;

DOI:10.1021/jm401902n

Reference yield: 83.0%

3-chloro-3-oxopropanoic acid methyl ester (37517-81-0) + methyl 2-{[(phenylmethyl)oxy]amino}-3-pyridine carboxylate (1312356-04-9) → methyl 2-(N-(benzyloxy)-3-methoxy-3-oxopropanamido)nicotinate (1561139-51-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jm401902n

upstream raw materials:

methyl 2-fluoro-3-pyridinecarboxylate

N-benzyloxyamine

2-{[(phenylmethyl)oxy]amino}-3-pyridinecarboxylic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

methyl 1-(benzyloxy)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

N-(3-chloro-4-fluorobenzyl)-1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

N-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

N-(3,4-difluorobenzyl)-1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide