(9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate

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Chemical Name:(9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate
CAS No.:1359084-97-1
Molecular Formula:C₃₆H₃₈F₃N₃O₆
Molecular Weight:665.709
Hs Code.:

Synonyms:(9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate

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Chemical Property of (9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate

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Technology Process of (9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate

There total 1 articles about (9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 1095037-98-1
(9H-fluoren-9-yl)methyl (S)-2-(isocyanomethyl)pyrrolidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1359084-97-1
(9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate

Guidance literature:: formaldehyd; L-leucine; trifluoroacetic acid; benzyl alcohol; at 20 ℃; for 0.333333h;

(9H-fluoren-9-yl)methyl (S)-2-(isocyanomethyl)pyrrolidine-1-carboxylate; at 20 ℃; for 2h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2011.12.037

Reference yield: 90.0%

: 1359084-97-1
(9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate

: 1359085-18-9
(S)-(9H-fluoren-9-yl)methyl 2-((2-((S)-1-(benzyloxy)-3-methyl-1-oxobutan-2-ylamino)acetamido)methyl)pyrrolidine-1-carboxylate

Guidance literature:: (9H-fluoren-9-yl)methyl 2-((2-(N-(1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)-2,2,2-trifluoroacetamido)acetamido)methyl)pyrrolidine-1-carboxylate; With toluene-4-sulfonic acid; In methanol; at 50 ℃; for 0.5h;

With triethylamine; In methanol; at 20 ℃; optical yield given as %de;
DOI:10.1016/j.tet.2011.12.037