(2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

Base Information

Chemical Name:(2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide
CAS No.:1443763-71-0
Molecular Formula:C₂₈H₂₅FN₆O₄S
Molecular Weight:560.609
Hs Code.:

Synonyms:(2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

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Chemical Property of (2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

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Technology Process of (2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

There total 21 articles about (2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34837-84-8
4-fluorobenzeneacetic acid methyl ester

: 1443763-71-0
(2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

Guidance literature:: Multi-step reaction with 5 steps

1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C

2: potassium hydroxide / ethanol; water / 4 h / 0 °C

3: (S)-1-phenyl-ethylamine / ethyl acetate / 1 h / 20 °C / Reflux

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 72 h / 20 °C

5: dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate monohydrate / toluene; 1-methyl-pyrrolidin-2-one / 2 h / Inert atmosphere; Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; potassium phosphate monohydrate; dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; (S)-1-phenyl-ethylamine; sodium hydrogencarbonate; diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1443764-09-7
tert-butyl [(1R)-1-(4-fluorophenyl)-2-{[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]amino}-2-oxoethyl]carbamate

: 1443763-71-0
(2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 74h;

Reference yield:

: 1539264-92-0
(4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)boronic acid

: 1539264-95-3
4-[(6-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)amino]-3-methoxy-N,N-dimethylbenzamide

: 1443763-71-0
(2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate monohydrate; dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; In 1-methyl-pyrrolidin-2-one; toluene; for 2h; Inert atmosphere; Reflux;