4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide

Base Information

Chemical Name:4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide
CAS No.:1355590-60-1
Molecular Formula:C₂₂H₂₂ClN₃O₄
Molecular Weight:427.887
Hs Code.:

Synonyms:4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide

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Chemical Property of 4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide

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Technology Process of 4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide

There total 5 articles about 4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₈H₁₀ClNO₃

: 787-59-7
N-(2-methoxyphenyl)-4-aminobenzamide

: 1355590-60-1
4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 16h;
DOI:10.1021/jm2010223

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 1355590-60-1
4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3 h / Reflux

2: palladium on activated charcoal; hydrogen / ethanol / 16 h / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 16 h / 120 °C

With pyridine; palladium on activated charcoal; hydrogen; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2010223

Reference yield:

: 24367-68-8
N-(2-methoxyphenyl)-4-nitrobenzamide

: 1355590-60-1
4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethanol / 16 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 16 h / 120 °C

With palladium on activated charcoal; hydrogen; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2010223