24367-68-8

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 122-04-3 4-nitro-benzoyl chloride 
• 3743-17-7 N-(2-hydroxy-phenyl)-4-nitro-benzamide 
• 74-88-4 methyl iodide 
• 95-55-6 2-amino-phenol 
• 62-23-7 4-nitro-benzoic acid 
• 24367-70-2 N-(2-methoxyphenyl)-4-nitrothiobenzamide 

Downstream Products

• 24367-70-2 N-(2-methoxyphenyl)-4-nitrothiobenzamide 
• 1355590-51-0 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide 
• 1355590-54-3 4-(3-chloro-4-(dimethylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide 
• 1355590-57-6 4-(3-(azetidin-1-yl)-4-chloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide 
• 1355590-60-1 4-(3-chloro-4-(isobutylamino)-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-methoxyphenyl)benzamide 
• 787-59-7 N-(2-methoxyphenyl)-4-aminobenzamide 
• 169947-42-6 4-Trifluoroacetylamino-N-{2-[4-(4-fluorobenzoyl)-piperidino]ethyl}-N-(2-methoxyphenyl)benzamide 
• 169946-75-2 4-Amino-N-{2[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxy-phenyl)benzamide 
• 1026680-98-7 acetic acid 2-(4-acetylamino-3-chloro-phenyl)-benzothiazol-4-yl ester 
• 247080-34-8 2-(4-amino-3-iodophenyl)-4-methoxybenzothiazole 
• 247080-36-0 2-(4-amino-3-chloro-phenyl)-benzothiazol-4-ol 
• 247080-52-0 2-(4-amino-3-chlorophenyl)-4-methoxybenzothiazole 
• 247080-33-7 4-hydroxy-2-(4-aminophenyl)-1,3-benzothiazole 
• 247080-19-9 4-methoxy-2-(4-nitrophenyl)-1,3-benzothiazole 

Relevant academic research and scientific papers

Synthesis, characterization and density functional theory investigations of monoacyl aniline derivatives

We synthesized a number of aniline derivatives containing acyl groups to compare their barriers of rotation around the N-CO groups. Geometry optimization for all the rotamers have been performed using density functional theory (DFT) at the B3LYP/6-31G** level of theory. For each stationary point we carried out vibrational frequency calculations at the same level to characterize their nature as minima or transition states. The methoxy group substituent on the benzene ring causes some changes in the C-C bond distances. We carried out potential energy surface scanning to find out all possible low-energy conformations, which would be used as the initial structure for further molecular calculations. There were only three kinds of conformations with local minimum potential energy and two transition states. The optimized bond lengths and bond angles are in better agreement with the experimental values.

WNT INHIBITORS FOR HUMAN STEM CELL DIFFERENTIATION

Methods and small molecule compounds for stem cell differentiation and treatment of animals with diseases are provided. One example of a class of compounds that may be used is represented by the compound of Formula I and II: or a pharmaceutically acceptab

Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: A structure-activity relationship study based on inhibitors for the Wnt response

Human embryonic stem cell-based high-content screening of 550 known signal transduction modulators showed that one "lead" (1, a recently described inhibitor of the proteolytic degradation of Axin) stimulated cardiomyogenesis. Because Axin controls canonical Wnt signaling, we conducted an investigation to determine whether the cardiogenic activity of 1 is Wnt-dependent, and we developed a structure-activity relationship to optimize the cardiogenic properties of 1. We prepared analogues with a range of potencies (low nanomolar to inactive) for Wnt/β-catenin inhibition and for cardiogenic induction. Both functional activities correlated positively (r 2 = 0.72). The optimal compounds induced cardiogenesis 1.5-fold greater than 1 at 30-fold lower concentrations. In contrast, no correlation was observed for cardiogenesis and modulation of transforming growth factor β (TGFβ)/Smad signaling that prominently influences cardiogenesis. Taken together, these data show that Wnt signaling inhibition is essential for cardiogenic activity and that the pathway can be targeted for the design of druglike cardiogenic molecules.

Transformation of thioamide compounds to corresponding amides using 12-Tungstosilicic acid

12-Tungstosilicic acid (H4SiW12O40) is applied for the conversion of a series of thioamides to their corresponding oxo analogues in excellent yields in acetonitrile. In the case of thioketones, no reaction is observed under these conditions. The reusability of the catalyst also is investigated.

11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer's disease

Pittsburgh Compound-B (PIB) is currently being evaluated clinically for in vivo visualization of amyloid plaques in patients with Alzheimer's disease (AD). We have synthesized three structural isomers of 6-hydroxy-2-(4′-aminophenyl)-1,3-benzothiazole, per

Desulfurization of Thioamides into Amides with H2O 2/ZrCl4 Reagent System

The hydrogen peroxide/zirconium(IV) chloride reagent system has been used as a new and efficient reagent for the deprotection/desulfurization of thioamides to amides. This system is reasonably general and can be applied to the conversion of several thioamides to the corresponding amides. The salient features of this protocol are short reaction times, good chemoselectivity, cleaner reaction profiles, and simple workup that precludes the use of toxic solvents. Georg Thieme Verlag Stuttgart.

Acidified, wet, silica-supported tetrabutylammonium periodate: A convenient and mild reagent for conversion of thioamides to their corresponding amides under solvent-free conditions

A series of thioamides are transformed to their corresponding oxo analogues in good to excellent yields with acidified, wet, silica-supported tetrabutylammonium periodate under solvent-free conditions.

A mild and convenient method for conversion of thioamides to their corresponding amides using acidified wet silica-supported permanganate under solvent-free conditions

A mild and efficient method for conversion of thioamides to their corresponding amides is reported. A series of thioamides are transformed to their corresponding carbonyl compounds in good to excellent yields by acidified wet silica-supported permanganate under solid phase conditions.

Efficient and convenient deprotection of thiocarbonyl to carbonyl compounds using 3-carboxypyridinium and 2,2′-bipyridinium chlorochromates in solution, dry media, and under microwave irradiation

A synthetic utility of 3-carboxypyridinium (CPCC) and 2,2′- bipyridinium (BPCC) chlorochromates in deprotection reactions is reported. Different types of thioamides, thioureas, thiono esters, and thioketones are deprotected to their corresponding carbonyl compounds with these reagents in good to excellent yields. The reactions were carried out in solution, under solvent-free conditions, and under microwave irradiation. The results show that with both reagents the rates of the reactions and the yields are usually highest under microwave irradiation. Springer-Verlag 2003.

Bismuth(III) nitrate pentahydrate: A convenient and selective reagent for conversion of thiocarbonyls to their carbonyl compounds

A variety of thioamides and thioureas are rapidly transformed to their oxo derivatives with Bi(NO3)3·5H2O in excellent yields. However, thiono esters and thioketones are converted to their corresponding carbonyl compounds in only poor yields. Bi(NO3)3·5H2O is relatively non-toxic, insensitive to air and inexpensive. These features coupled with the selective deprotection of thioamides and thioureas in the presence of thiono esters and thioketones make this method an attractive alternative to the existing routes for deprotection of thiocarbonyl compounds.