methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate

Base Information

• Chemical Name: methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate
• CAS No.: 1268729-61-8
• Molecular Formula: C₂₆H₄₁N₃O₇
• Molecular Weight: 507.627
• Mol file: 1268729-61-8.mol

Synonyms:methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate

Chemical Property of methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate

There total 4 articles about methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Boc-Lys(Z)-OH (2389-45-9) + H-D-N-MeVal-OMe*HCl (1268729-60-7) → methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate (1268729-61-8)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 24h;

DOI:10.1002/hlca.201100437

Reference yield: 89.0%

Boc-Lys(Z)-OH (2389-45-9) + methyl N-Methyl-D-valinate (769890-37-1) → methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate (1268729-61-8)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;

DOI:10.3390/md10061307

Reference yield:

Boc-D-Val-OH (22838-58-0) → methyl N2-[(tert-butoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valinate (1268729-61-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 20 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine

With sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.3390/md10061307

upstream raw materials:

Boc-Lys(Z)-OH

methyl N-Methyl-D-valinate

Boc-D-Val-OH

(R)-2-(tert-butoxycarbonyl(methyl)amino)-3-methylbutanoic acid

Downstream raw materials:

methyl N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valyl-N-methyl-D-alaninate

C₂₉H₄₆N₄O₈

N₂-[(tert-butoxy)carbonyl]-N₆-[(phenylmethoxy)carbonyl]-L-lysyl-N-methyl-D-valine