1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone

Base Information

Chemical Name:1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone
CAS No.:179694-26-9
Molecular Formula:C₂₇H₂₉ClN₂O₂
Molecular Weight:448.992
Hs Code.:

Synonyms:1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone

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Chemical Property of 1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone

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Technology Process of 1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone

There total 1 articles about 1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 17078-28-3
2-[4-(dimethylamino)phenyl]acetic acid

: 73445-60-0
(+/-)-7-chloro-8-methoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

: 179694-26-9
1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1021/jm960143p

Reference yield: 60.0%

: 179694-26-9
1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone

: 179694-28-1
{4-[2-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethyl]-phenyl}-dimethyl-amine

Guidance literature:: With aluminium hydride; sulfuric acid; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1021/jm960143p

Reference yield:

: 179694-26-9
1-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone

: 8-Chloro-3-[2-(4-dimethylamino-phenyl)-ethyl]-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / AlH₃, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 70 percent / BBr₃ / CHCl₃; CH₂Cl₂ / 1 h / Ambient temperature

With aluminium hydride; sulfuric acid; boron tribromide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jm960143p