2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone

Base Information

• Chemical Name: 2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone
• CAS No.: 1612759-99-5
• Molecular Formula: C₁₆H₁₃F₃O₃S
• Molecular Weight: 342.339
• Mol file: 1612759-99-5.mol

Synonyms:2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone

Chemical Property of 2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone

Chemical Property:

Purity/Quality:

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Technology Process of 2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone

There total 23 articles about 2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (383-53-9) + sodium 4-methylbenzenesulfinate (824-79-3) → 2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone (1612759-99-5)

Guidance literature:

In 1,4-dioxane; water; Reflux;

DOI:10.1055/s-0036-1589479

Reference yield: 97.0%

1-trifluoromethyl-4-vinyl-benzene (402-50-6) + sodium 4-methylbenzenesulfinate (824-79-3) → 2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone (1612759-99-5)

Guidance literature:

With hydrogenchloride; In water; N,N-dimethyl-formamide; at 30 ℃; for 14h; Sealed tube;

Reference yield: 94.0%

1-(4-(trifluoromethyl)phenyl)vinyl 4-methylbenzenesulfonate → 2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone (1612759-99-5)

Guidance literature:

With eosin B disodium salt; In dimethyl sulfoxide; at 20 ℃; for 1h; Reagent/catalyst; Solvent; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1039/c7gc01467h

upstream raw materials:

4'-(trifluoromethyl)acetophenone acetyloxime

sodium 4-methylbenzenesulfinate

toluene-4-sulfonic acid hydrazide

N-(1-(4-(trifluoromethyl)phenyl)vinyl)acetamide

Downstream raw materials:

2-(toluene-4-sulfonyl)-1-(4-trifluoromethylphenyl)ethanone oxime