(5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione

Base Information

Chemical Name:(5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione
CAS No.:84066-35-3
Molecular Formula:C₂₂H₂₆O₅
Molecular Weight:370.445
Hs Code.:

Synonyms:(5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione

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Chemical Property of (5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione

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Technology Process of (5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione

There total 3 articles about (5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3Z,7E)-(1S,5S,10S)-5-Benzyloxymethoxy-4,8-dimethyl-bicyclo[8.2.0]dodeca-3,7-diene-2,11-dione

: 84066-35-3
(5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione

Guidance literature:: With titanium(IV) isopropylate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In diethyl ether; at -30 ℃; for 0.25h;
DOI:10.1021/ja00341a055

Reference yield:

: 84066-34-2
(3Z,7E)-(1S,5S,10S)-5-Benzyloxymethoxy-11,11-dimethoxy-4,8-dimethyl-bicyclo[8.2.0]dodeca-3,7-dien-2-one

: 84066-35-3
(5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: (COOH)2/silica gel / CH₂Cl₂ / 2 h / 35 °C

2: H₂O₂, Ti(O-i-Pr)4, i-Pr₂NEt / diethyl ether / 0.25 h / -30 °C

With titanium(IV) isopropylate; dihydrogen peroxide; oxalic acid; silica gel; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00341a055

Reference yield:

: 84066-33-1
(1S,4S,6S)-4-Benzyloxymethoxy-1-(3,3-dimethoxy-cyclobut-1-enyl)-6-isopropenyl-3-methyl-cyclohex-2-enol

: 84066-35-3
(5Z,9E)-(3aS,7S,11aS)-7-Benzyloxymethoxy-6,10-dimethyl-3,3a,7,8,11,11a-hexahydro-cyclodeca[b]furan-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / methanol / 24 h / 25 °C

2: (COOH)2/silica gel / CH₂Cl₂ / 2 h / 35 °C

3: H₂O₂, Ti(O-i-Pr)4, i-Pr₂NEt / diethyl ether / 0.25 h / -30 °C

With titanium(IV) isopropylate; dihydrogen peroxide; oxalic acid; silica gel; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja00341a055