(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

Base Information

Chemical Name:(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester
CAS No.:582313-78-8
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

Suppliers and Price of (5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

There total 1 articles about (5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 100-52-7
benzaldehyde

: (2,2-dimethyltetrahydro[1,3]dioxol[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

: 582313-78-8
(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 24h;
DOI:10.1248/cpb.51.276

Reference yield: 86.0%

: 582313-78-8
(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

: 582313-79-9
2-(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)ethanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1248/cpb.51.276

Reference yield:

: 582313-78-8
(5-benzyl-2,2-dimethyltetrahydro[1,3]dioxolo[4,5-c]pyrrol-4-yl)acetic acid ethyl ester

: 582313-89-1
4-[2-(3,4-diethoxy-1-methylpyrrolidin-2-yl)ethoxy]benzaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: 86 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

2: 93 percent / DMAP; pyridine / 2 h / 20 °C

3: aq. TFA / 24 h / 20 °C

4: 2.18 g / NaH; TBAI / dimethylformamide / 2 h / 0 °C

5: 76 percent / H₂ / 20 percent Pd(OH)2/C / methanol / 24 h

6: 61 percent / NaBH₃CN; AcOH / methanol / 24 h / 20 °C

7: 83 percent / NaOMe / methanol / 2 h / 20 °C

8: 75 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 24 h

With pyridine; dmap; hydrogen; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 8: Mitsunobu reaction;
DOI:10.1248/cpb.51.276