2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Base Information

Chemical Name:2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide
CAS No.:1258458-61-5
Molecular Formula:C₂₂H₁₉N₃O₄S
Molecular Weight:421.477
Hs Code.:

Synonyms:2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

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Chemical Property of 2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

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Technology Process of 2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

There total 15 articles about 2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1007873-66-6
2-methyl-5-(m-tolyl)oxazole-4-carboxylic acid

: 1258459-39-0
1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

: 1258458-61-5
2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Guidance literature:: 2-methyl-5-(m-tolyl)oxazole-4-carboxylic acid; With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 33166-79-9
ethyl m-toluoylacetate

: 1258458-61-5
2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; acetic acid / water / 2.25 h / 10 - 20 °C / Inert atmosphere

2.1: sodium acetate; acetic acid / mercury dichloride / water / 1 h / Reflux

3.1: thionyl chloride / chloroform / 2.5 h / 0 °C / Reflux; Inert atmosphere

4.1: sodium hydroxide; water / tetrahydrofuran / 3 h

4.2: pH 3 - 4 / Cooling with ice

5.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.2: 16 h / 20 °C / Inert atmosphere

With dmap; thionyl chloride; water; sodium acetate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium nitrite; mercury dichloride; In tetrahydrofuran; dichloromethane; chloroform; water;

Reference yield:

: C₁₂H₁₃NO₄

: 1258458-61-5
2-methyl-5-m-tolyl-oxazole-4-carboxylic acid [2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; acetic acid / mercury dichloride / water / 1 h / Reflux

2.1: thionyl chloride / chloroform / 2.5 h / 0 °C / Reflux; Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran / 3 h

3.2: pH 3 - 4 / Cooling with ice

4.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

With dmap; thionyl chloride; water; sodium acetate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; mercury dichloride; In tetrahydrofuran; dichloromethane; chloroform; water;