1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

Base Information

Chemical Name:1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride
CAS No.:1258459-39-0
Molecular Formula:C₁₀H₁₀N₂O₂S*ClH
Molecular Weight:258.729
Hs Code.:

Synonyms:1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

Suppliers and Price of 1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

There total 10 articles about 1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258459-38-9
[2-(5-acetyl-furan-2-ylmethyl)-thiazol-4-yl]-carbamic acid tert-butyl ester

: 1258459-39-0
1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 17h; Inert atmosphere;

Reference yield:

: 1192-62-7,80145-44-4
1-(2-furyl)-1-ethanone

: 1258459-39-0
1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium tetrafluoroborate / ethylene glycol / 95 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 1.08 h / 0 - 20 °C / Inert atmosphere

4.1: dmap; triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5.1: dimethyl sulfoxide / 0.75 h / 80 °C / Inert atmosphere

6.1: sodium methylate; hexamethyldisilathiane / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

7.1: ethanol / 0.5 h / Inert atmosphere; Reflux

8.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

9.1: triethylamine; diphenyl phosphoryl azide / toluene / 2.08 h / 20 - 90 °C / Inert atmosphere

9.2: 1 h / Inert atmosphere; Reflux

10.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 17 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; dmap; sodium tetrahydroborate; lithium tetrafluoroborate; n-butyllithium; hexamethyldisilathiane; diphenyl phosphoryl azide; water; sodium methylate; methanesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; ethylene glycol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 9.1: Curtius Rearrangement / 9.2: Curtius Rearrangement;

Reference yield:

: 69536-36-3
2-(furan-2-yl)-2-methyl-[1,3]dioxolane

: 1258459-39-0
1-[5-(4-amino-thiazol-2-ylmethyl)-furan-2-yl]-ethanone hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sodium tetrahydroborate; methanol / 1.08 h / 0 - 20 °C / Inert atmosphere

3.1: dmap; triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: dimethyl sulfoxide / 0.75 h / 80 °C / Inert atmosphere

5.1: sodium methylate; hexamethyldisilathiane / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

6.1: ethanol / 0.5 h / Inert atmosphere; Reflux

7.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

8.1: triethylamine; diphenyl phosphoryl azide / toluene / 2.08 h / 20 - 90 °C / Inert atmosphere

8.2: 1 h / Inert atmosphere; Reflux

9.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 17 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; dmap; sodium tetrahydroborate; n-butyllithium; hexamethyldisilathiane; diphenyl phosphoryl azide; water; sodium methylate; methanesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 8.1: Curtius Rearrangement / 8.2: Curtius Rearrangement;