2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

Base Information

Chemical Name:2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate
CAS No.:1217396-92-3
Molecular Formula:C₇H₈O₃S*C₂₅H₃₃F₃N₄O₃
Molecular Weight:666.762
Hs Code.:

2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

Synonyms:2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

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Chemical Property of 2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

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Technology Process of 2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

There total 4 articles about 2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1217413-72-3
tert-butyl (2R)-2-{[2-({(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}carbamoyl)-4-(trifluoromethyl)phenoxy]methyl}azetidine-1-carboxylate

: 104-15-4
toluene-4-sulfonic acid

: 1217396-92-3
2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

Guidance literature:: tert-butyl (2R)-2-{[2-({(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}carbamoyl)-4-(trifluoromethyl)phenoxy]methyl}azetidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

toluene-4-sulfonic acid; In ethyl acetate; at 20 ℃; for 6h;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1217396-92-3
2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 85 °C

1.2: 20 °C

2.1: triethylamine / tetrahydrofuran / 3.17 h / 20 °C

3.1: toluene / 90 °C

4.1: potassium-t-butoxide / tetrahydrofuran / 0.33 h / 20 °C

4.2: 6 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.2: 6 h / 20 °C

With potassium-t-butoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1140917-39-0
(R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine

: 1217396-92-3
2-[(2R)-azetidin-2-ylmethoxy]-N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-5-(trifluoromethyl)benzamide p-toluensulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 3.17 h / 20 °C

2.1: toluene / 90 °C

3.1: potassium-t-butoxide / tetrahydrofuran / 0.33 h / 20 °C

3.2: 6 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.2: 6 h / 20 °C

With potassium-t-butoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;