59997-51-2Relevant articles and documents
A simplified method for the efficient preparation of pivaloylacetonitrile
Zelinka, Karel,Simbera, Jan,Pazdera, Pavel
, p. 386 - 389 (2014)
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Identification of TRD-35 as Potent and Selective DRAK2 Inhibitor
Ali, Imran,Park, Sangjun,Jung, Myoung Eun,Lee, Nari,Bibi, Maimoona,Chae, Chong Hak,Yang, Kyung-Min,Kim, Seong-Jin,Choi, Gildon,Lee, Kwangho
, p. 567 - 569 (2020/03/23)
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A green, economical synthesis of β-ketonitriles and trifunctionalized building blocks from esters and lactones
Pienaar, Daniel P.,Butsi, Kamogelo R.,Rousseau, Amanda L.,Brady, Dean
supporting information, p. 2930 - 2935 (2019/12/23)
The acylation of the acetonitrile anion with lactones and esters in ethereal solvents was successfully exploited using inexpensive KOt-Bu to obtain a variety of β-ketonitriles and trifunctionalized building blocks, including useful O-unprotected diols. It was discovered that lactones react to produce the corresponding derivatized cyclic hemiketals. Furthermore, the addition of a catalytic amount of isopropanol, or 18-crown-6, was necessary to facilitate the reaction and to reduce side-product formation under ambient conditions.