2-[(1S,9S,10R)-4-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-17-yl]-1-phenylethanone

Base Information

• Chemical Name: 2-[(1S,9S,10R)-4-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-17-yl]-1-phenylethanone
• CAS No.: 10061-32-2
• Molecular Formula: C24H27 N O2
• Molecular Weight: 361.484
• European Community (EC) Number: 233-198-4
• Nikkaji Number: J9.656C
• Wikipedia: Levophenacylmorphan
• Mol file: 10061-32-2.mol

Synonyms:10061-32-2

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Chemical Property of 2-[(1S,9S,10R)-4-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-17-yl]-1-phenylethanone

Chemical Property:

• Vapor Pressure: 6.67E-13mmHg at 25°C
• Melting Point: 173-175 °C
• Boiling Point: 554.5°C at 760 mmHg
• PKA: 10.15±0.20(Predicted)
• Flash Point: 289.1°C
• PSA: 40.54000
• Density: 1.24g/cm³
• LogP: 4.27140
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 361.204179104
• Heavy Atom Count: 27
• Complexity: 557

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC23CCN(C(C2C1)CC4=C3C=C(C=C4)O)CC(=O)C5=CC=CC=C5
• Isomeric SMILES: C1CC[C@]23CCN([C@H]([C@@H]2C1)CC4=C3C=C(C=C4)O)CC(=O)C5=CC=CC=C5
• Uses: As Morphinan derivative, levophenacylmorphan can be useful as antitussive and analgesic.

Technology Process of 2-[(1S,9S,10R)-4-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-17-yl]-1-phenylethanone

There total 1 articles about 2-[(1S,9S,10R)-4-hydroxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-17-yl]-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-bromoacetophenone (70-11-1) + norlevorphanol (1531-12-0) → 17-phenacyl-morphinan-3-ol (10061-32-2)

Guidance literature:

With potassium carbonate; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19570400514

upstream raw materials:

α-bromoacetophenone

norlevorphanol