2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester

Base Information

• Chemical Name: 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester
• CAS No.: 159213-95-3
• Molecular Formula: C₁₇H₁₉NO₅S
• Molecular Weight: 349.408
• Mol file: 159213-95-3.mol

Synonyms:2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester

Chemical Property of 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester

There total 5 articles about 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-[3-(phenylsulfonyl)aminophenoxy]-acetic acid ethyl ester (159213-86-2) + methyl iodide (74-88-4) → 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester (159213-95-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/jm021028j

Reference yield:

meta-nitrophenol (554-84-7) → 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester (159213-95-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 53 h / 70 - 130 °C

2: 96 percent / H₂ / Pt(IV)O₂ / ethanol / 20 °C

3: 88 percent / pyridine / CH₂Cl₂ / 20 °C

4: 86 percent / K₂CO₃ / dimethylformamide / 1 h

With pyridine; hydrogen; potassium carbonate; platinum(IV) oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm021028j

Reference yield:

2-(3-nitrophenoxy)-acetic acid ethyl ester (5544-77-4) → 2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid ethyl ester (159213-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / H₂ / Pt(IV)O₂ / ethanol / 20 °C

2: 88 percent / pyridine / CH₂Cl₂ / 20 °C

3: 86 percent / K₂CO₃ / dimethylformamide / 1 h

With pyridine; hydrogen; potassium carbonate; platinum(IV) oxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm021028j

upstream raw materials:

2-[3-(phenylsulfonyl)aminophenoxy]-acetic acid ethyl ester

methyl iodide

meta-nitrophenol

3-aminophenoxyacetic acid ethyl ester

Downstream raw materials:

2-[3-(phenylsulfonyl)-N-methylamino-phenoxy]-acetic acid

2-([3-(phenylsulfonyl)-N-methylamino-phenoxy]-4-pyridyl) acetamide