Technology Process of diethyl (3,5-di-tert-butyl-4-fluorobenzyl)malonate
There total 3 articles about diethyl (3,5-di-tert-butyl-4-fluorobenzyl)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
diethyl malonate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.5h;
Inert atmosphere;
5-(bromomethyl)-1,3-ditert-butyl-2-fluorobenzene;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 2.16667h;
Inert atmosphere;
DOI:10.1021/np500260z
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 12 h / 0 - 20 °C / Inert atmosphere
2.1: N-Bromosuccinimide; Perbenzoic acid / tetrachloromethane / 3 h / Reflux; Inert atmosphere
3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 2.17 h / 0 - 20 °C / Inert atmosphere
With
aluminum (III) chloride; N-Bromosuccinimide; Perbenzoic acid; sodium hydride;
In
tetrahydrofuran; tetrachloromethane; mineral oil;
1.1: |Friedel-Crafts Alkylation;
DOI:10.1021/np500260z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide; Perbenzoic acid / tetrachloromethane / 3 h / Reflux; Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 2.17 h / 0 - 20 °C / Inert atmosphere
With
N-Bromosuccinimide; Perbenzoic acid; sodium hydride;
In
tetrahydrofuran; tetrachloromethane; mineral oil;
DOI:10.1021/np500260z
