4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

Base Information

Chemical Name:4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester
CAS No.:1350440-92-4
Molecular Formula:C₆₀H₅₆N₈O₇S
Molecular Weight:1033.22
Hs Code.:

4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

Synonyms:4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

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Chemical Property of 4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

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Technology Process of 4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

There total 3 articles about 4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 299176-17-3
N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester

: 1350440-91-3
4-(4-hydroxyphenylthiomethyl)-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

: 1350440-92-4
4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

Guidance literature:: 4-(4-hydroxyphenylthiomethyl)-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.333333h;

N-(2-nitro-5-chlorophenyl)-N-methylcarbamic acid t-butyl ester; In N,N-dimethyl-formamide; mineral oil; at 70 ℃; for 17h;

Reference yield:

: 124750-61-4
2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-4,5-dicarboxylic acid dimethyl ester

: 1350440-92-4
4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.55 h / 20 °C / Cooling with acetone-dry ice

2.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Cooling with ice

2.2: 20 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

3.2: 17 h / 70 °C

With sodium hydride; diisobutylaluminium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 150690-76-9
4-hydroxymethyl-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

: 1350440-92-4
4-[4-{3-(N-t-butoxycarbonyl-N-methylamino)-4-nitrophenoxy}phenylthiomethyl]-2-propyl-1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-imidazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 72 h / 20 °C / Cooling with ice

1.2: 20 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

2.2: 17 h / 70 °C

With sodium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;