tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate

Base Information

• Chemical Name: tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate
• CAS No.: 1265323-47-4
• Molecular Formula: C₃₀H₃₄N₄O₅
• Molecular Weight: 530.624
• Mol file: 1265323-47-4.mol

Synonyms:tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate

Chemical Property of tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate

There total 8 articles about tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl azetidine-3-carboxylate (790600-78-1) + 2-bromo-1-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol (1265323-46-3) → tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate (1265323-47-4)

Guidance literature:

With acetic acid; triethylamine; In dimethyl sulfoxide; at 80 ℃; for 2h;

Reference yield:

O1-benzyl-O3-tert-butylazetidine-1,3-dicarboxylate (1236144-51-6) → tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate (1265323-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2206.72 Torr

2: triethylamine; acetic acid / dimethyl sulfoxide / 2 h / 80 °C

With hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In dimethyl sulfoxide; ethyl acetate;

Reference yield:

1-phenyl-1-pentyne (4250-81-1) → tert-butyl 1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)azetidine-3-carboxylate (1265323-47-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 18 h / 160 °C

2: sodium hydroxide / ethanol / 2 h / 75 °C

3: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

6: triethyl-bromo-silane / tetrahydrofuran / 1 h / -78 °C

7: triethylamine; acetic acid / dimethyl sulfoxide / 2 h / 80 °C

With pyridine; trifluoro-[1,3,5]triazine; triethyl-bromo-silane; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

upstream raw materials:

1-phenyl-1-pentyne

tert-butyl azetidine-3-carboxylate

2-bromo-1-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethanol

O₁-benzyl-O₃-tert-butylazetidine-1,3-dicarboxylate