tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate
CAS No.:1218761-39-7
Molecular Formula:C₂₄H₂₈Cl₃N₃O₃
Molecular Weight:512.864
Hs Code.:

Synonyms:tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate

There total 1 articles about tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1218761-38-6
tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)carbamoyl]amino}pyrrolidine-1-carboxylate

: 74-88-4
methyl iodide

: 1218761-39-7
tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)carbamoyl]amino}pyrrolidine-1-carboxylate; With sodium hydride; In ISOPROPYLAMIDE; at 0 ℃; for 0.0833333h;

methyl iodide; In ISOPROPYLAMIDE; at 10 - 35 ℃; for 2h;

Reference yield: 98.0%

: 1218761-39-7
tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate

: 1218761-40-0
1-[(3S,4R)-4-(4-chlorophenyl)pyrrolidin-3-yl]-3-(3,5-dichlorophenyl)-1,3-dimethylurea monohydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 50 ℃; for 2h;

Reference yield:

: 1218761-39-7
tert-butyl (3R,4S)-3-(4-chlorophenyl)-4-{[(3,5-dichlorophenyl)(methyl)carbamoyl](methyl)amino}pyrrolidine-1-carboxylate

: 1218761-41-1
1-[(3S,4R)-4-(4-chlorophenyl)-1-{[4-(methylsulfonyl)piperazin-1-yl]carbonyl}pyrrolidin-3-yl]-3-(3,5-dichlorophenyl)-1,3-dimethylurea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / isopropyl alcohol / 2 h / 50 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 5 °C

3: 1-methyl-pyrrolidin-2-one / 11 h / 135 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; isopropyl alcohol;