[(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
• CAS No.: 84047-95-0
• Molecular Formula: C₃₉H₅₆ClN₉O₁₀
• Molecular Weight: 846.381
• Mol file: 84047-95-0.mol

Synonyms:[(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property of [(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

There total 4 articles about [(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-chloroethyl isothiocyanate (1943-83-5) + [(S)-1-[({[((S)-1-{(S)-1-[N'-(3-Amino-propionyl)-hydrazinocarbonyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester; compound with acetic acid (103310-91-4) → [(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (84047-95-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;

Reference yield:

[(S)-1-[({[((S)-1-{(S)-1-[N'-(3-Benzyloxycarbonylamino-propionyl)-hydrazinocarbonyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (84047-93-8) → [(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (84047-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / 50percent acetic acid, H₂ / Pd/C / methanol / 3 h

2: 77 percent / triethylamine / dimethylformamide / 3 h / Ambient temperature

With hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-OMe (68835-86-9) → [(S)-1-({[({(S)-1-[(S)-1-(N'-{3-[3-(2-Chloro-ethyl)-ureido]-propionyl}-hydrazinocarbonyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-methyl)-carbamoyl]-methyl}-carbamoyl)-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (84047-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 86.6 percent / 98percent hydrazine hydrate / dimethylformamide / 24 h

2: 1.) 1-hydroxybenzotriazole, 2.) dicyclohexylcarbodiimide / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, 1 h, r.t., 1 h

3: 75 percent / 50percent acetic acid, H₂ / Pd/C / methanol / 3 h

4: 77 percent / triethylamine / dimethylformamide / 3 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; hydrazine hydrate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

2-chloroethyl isothiocyanate

[(S)-1-[({[((S)-1-{(S)-1-[N'-(3-Amino-propionyl)-hydrazinocarbonyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester; compound with acetic acid

[(S)-1-[({[((S)-1-{(S)-1-[N'-(3-Benzyloxycarbonylamino-propionyl)-hydrazinocarbonyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Boc-L-Tyr-Gly-Gly-L-Phe-L-Leu-OMe

Downstream raw materials:

N^ω-(Q-β-alanyl)enkephalin hydrazide