4-HYDROXY-7-METHOXYCOUMARIN

Base Information

• Chemical Name: 4-HYDROXY-7-METHOXYCOUMARIN
• CAS No.: 17575-15-4
• Molecular Formula: C10H8O4
• Molecular Weight: 192.171
• Hs Code.: 29322985
• Mol file: 17575-15-4.mol

Synonyms:Coumarin,4-hydroxy-7-methoxy- (8CI);Herniarin, 4-hydroxy- (6CI);4-Hydroxy-7-methoxy-2H-1-benzopyran-2-one;4-Hydroxy-7-methoxycoumarin;7-Methoxy-4-hydroxycoumarin;

Chemical Property of 4-HYDROXY-7-METHOXYCOUMARIN

Chemical Property:

• Appearance/Colour: Brown solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 263-265 °C
• Refractive Index: 1.624
• Boiling Point: 390.141 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 161.977 °C
• PSA: 59.67000
• Density: 1.412 g/cm³
• LogP: 1.50720
• Storage Temp.: -20°C Freezer
• Solubility.: Acetone, DMSO

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-7-methoxycoumarin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxy-7-methoxycoumarin (cas# 17575-15-4) is a compound useful in organic synthesis.

Technology Process of 4-HYDROXY-7-METHOXYCOUMARIN

There total 18 articles about 4-HYDROXY-7-METHOXYCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) + Diethyl carbonate (105-58-8,76619-83-5) → 4-hydroxy-7-methoxycoumarine (17575-15-4)

Guidance literature:

With sodium hydride; In mineral oil; at 0 - 85 ℃; for 14h;

DOI:10.1016/j.bmcl.2020.127415

Reference yield: 96.0%

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) + carbon monoxide (201230-82-2) → 4-hydroxy-7-methoxycoumarine (17575-15-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 80 ℃; for 4h; under 7355.08 Torr;

DOI:10.1055/s-1988-27537

Reference yield: 92.0%

p-methoxybenzoylmethanol (4136-21-4) + Diethyl carbonate (105-58-8,76619-83-5) → 4-hydroxy-7-methoxycoumarine (17575-15-4)

Guidance literature:

p-methoxybenzoylmethanol; Diethyl carbonate; With sodium hydride; In toluene; for 0.5h; Cooling with ice;

In toluene; at 100 ℃; for 4h;

upstream raw materials:

4,7-dimethoxyy-2H-chromen-2-one

1-(2-hydroxy-4-methoxyphenyl)ethanone

Diethyl carbonate

O-methylresorcine

Downstream raw materials:

7-Methoxy-4-(2-oxo-cyclohexyloxy)-chromen-2-one

4-hydroxy-7-methoxy-3-phenylcoumarin

4-hydroxy-7-methoxy-3-(4-methoxyphenyl)-1-benzopyran-2-one

3-(2,4-dimethoxyphenyl)-4-hydroxy-7-methoxy-1-benzopyran-2-one