Tolnidamine

Base Information

• Chemical Name: Tolnidamine
• CAS No.: 50454-68-7
• Molecular Formula: C16H13ClN2O2
• Molecular Weight: 300.76
• Hs Code.: 2933990090
• Mol file: 50454-68-7.mol

Synonyms:Tolnidamine;1b,Indazole;AF 1923;Tolnidamide;

Chemical Property of Tolnidamine

Chemical Property:

• Vapor Pressure: 5.19E-12mmHg at 25°C
• Melting Point: 220°C (rough estimate)
• Refractive Index: 1.5200 (estimate)
• Boiling Point: 528.8°C at 760 mmHg
• Flash Point: 273.6°C
• PSA: 55.12000
• Density: 1.34g/cm³
• LogP: 3.74460

Purity/Quality:

99% ^*data from raw suppliers

TOLNIDAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tolnidamine

There total 1 articles about Tolnidamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Tolnidamine (50454-68-7)

Guidance literature:

Indazolsaeure-ethylester 1. NaOEt, 2-Me-4-ClC6H3CH2X (X: Halogen) 2. Esterverseifung mit KOH;

DOI:10.1021/jm00228a008

Reference yield:

Tolnidamine (50454-68-7) → C16H12Cl2N2O (1186610-42-3)

Guidance literature:

With thionyl chloride; at 50 - 80 ℃; for 5.5h;

Reference yield:

ethanol (64-17-5) + Tolnidamine (50454-68-7) → ethyl 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylate (1186610-38-7)

Guidance literature:

sulfuric acid; at 20 ℃; Reflux;

Downstream raw materials:

ethyl 1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxylate

C₁₆H₁₂Cl₂N₂O

1-(4-chloro-2-methylbenzyl)-1H-indazole-3-carboxaldehyde

2-[1-(4-chloro-2-methylbenzyl)-1H-indazol-3-yl]propan-2-ol