1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester
• CAS No.: 1229826-81-6
• Molecular Formula: C₁₉H₁₅N₃O₃S
• Molecular Weight: 365.412
• Mol file: 1229826-81-6.mol

Synonyms:1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester

Chemical Property of 1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester

There total 1 articles about 1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

methyl 2-methylchromone-3-carboxylate (51751-33-8) + 1,3-benzothiazol-2-ylhydrazine (615-21-4) → 1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1229826-81-6)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 20 ℃; for 4h; Reflux;

DOI:10.1016/j.ejmech.2010.02.050

Reference yield: 92.0%

1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1229826-81-6) + cobalt(II) perchlorate hexahydrate → [bis(1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-4-methoxycarbonyl-1H-pyrazole-N2,N3')-cobalt(II)]diperchlorate

Guidance literature:

In methanol; ethyl acetate; soln. of Co(ClO4)2*6H2O (0.055 mmol) added at room temp. to stirred soln. of N2C3(CH3)(CO2CH3)(C6H4(OH))NSC7H4 (0.11 mmol) (ethyl acetate), stirred and refluxed for 24 h; kept at room temp. by slow evapn. to Et2O, crystd. for 1 weeks; elem. anal.;

DOI:10.1016/j.ica.2010.03.011

Reference yield: 51.0%

cobalt(II) nitrate hexahydrate + 1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester (1229826-81-6) → 1-benzothiazol-2-yl-5-(2-hydroxyphenyl)-3-methyl-4-methoxycarbonyl-1H-pyrazole-N2,N3'-dinitrato-O,O'-cobalt(II)

Guidance literature:

In dichloromethane; Co(NO3)2*6H2O (0.1 mmol) added at room temp. to stirred soln. of N2C3(CH3)(CO2CH3)(C6H4(OH))NSC7H4 (0.1 mmol), stirred for 24 h; kept at room temp. by slow evapn. to Et2O, crystd. for 2 weeks; elem. anal.;

DOI:10.1016/j.ica.2010.03.011

upstream raw materials:

methyl 2-methylchromone-3-carboxylate

1,3-benzothiazol-2-ylhydrazine

Downstream raw materials:

C₁₉H₁₅Cl₂CuN₃O₃S