51751-33-8

Basic information

• Product Name: methyl 2-methyl-4-oxo-4H-chromene-3-carboxylate
• CAS NO: 51751-33-8
• Molecular Formula: C₁₂H₁₀O₄
• Molecular Weight: 218.2054
• Mol File: 51751-33-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 320.4°C at 760 mmHg
• Flash Point: 140.8°C
• Density: 1.278g/cm³
• Vapor Pressure: 0.000319mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: methyl 2-methyl-4-oxo-4H-chromene-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-methyl-4-oxo-4H-chromene-3-carboxylate(51751-33-8)
• EPA Substance Registry System: methyl 2-methyl-4-oxo-4H-chromene-3-carboxylate(51751-33-8)

Safety Data

• Hazardous Substances Data: 51751-33-8(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 51751-37-2 2-Methyl-4-oxo-4H-<1>benzopyran-3-carboxylic acid 
• 105-45-3 acetoacetic acid methyl ester 
• 393-52-2 2-Fluorobenzoyl chloride 
• 78589-59-0 3-(2-Acetoxy-phenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid methyl ester 
• 186581-53-3 diazomethane 
• 93562-17-5 methyl 4-oxo-4H-chromene-3-carboxylate 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 90-02-8 salicylaldehyde 
• 20349-86-4 Methyl 3-(2-hydroxy-phenyl)-3-oxopropanoate 
• 5538-51-2 O-acetylsalicyloyl chloride 
• 39079-62-4 chromone-3-carboxylic acid 

Downstream Products

• 2555-37-5 3-acetyl-4-hydroxychromen-2-one 
• 163041-14-3 Methyl 2,3-dihydro-2-methyl-2-[2-(2,2-dimethyl-6-methylenecyclohexyl)ethyl]-4-oxo-4H-1-benzopyran-3-carboxylate 
• 32595-98-5 4,5-Dihydro-2-methyl-3-furancarbonsaeure-methylester 
• 51751-37-2 2-Methyl-4-oxo-4H-<1>benzopyran-3-carboxylic acid 
• 1229826-81-6 1-(benzothiazol-2-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 1229826-84-9 1-(6-chloropyridazin-3-yl)-5-(2-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxylic acid methyl ester 
• 1204754-65-3 methyl 2-(3,4-dichlorophenyl)-2-methyl-4-oxochroman-3-carboxylate 
• 93318-01-5 2,3-dihydro-2,2-dimethyl-4H-1-benzopyran-4-one 2,4-dinitrophenylhydrazone 
• 124557-95-5 1-phenyl-5-(4-hydroxy-2-oxo-1-benzopyran-3-yl)-pyrazole 

Relevant articles and documents

An Improved Synthesis of 2-Methylchromone-3-carboxylic Acid and its Esters

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On-Water Cp?Ir(III)-catalyzed C-H functionalization for the synthesis of chromones through annulation of salicylaldehydes with diazo-ketones

A high-valent Ir(III)-catalyzed C-H bond functionalization is carried out for the first time on water for the synthesis of a biologically relevant chromone moiety. The C-H activation and annulation of salicylaldehydes with diazo-compounds provided the desired chromones. The synthesis of C3-substitution-free chromones has also been demonstrated by a one-pot decarboxylation by employing tert-butyl diazoester. C3 and C5 C-H activations of the product chromone are also carried out under different conditions for further diversification.

Cp?Ir(III)-Catalyzed C-H/O-H Functionalization of Salicylaldehydes for the Synthesis of Chromones at Room Temperature

Herein, we report Cp Ir(III)-catalyzed C-H/O-H-bond functionalization of salicylaldehydes with α-diazocarbonyl compounds for the synthesis of chromones under redox-neutral conditions. The reaction proceeds at room temperature and displays excellent functi