(S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

Base Information

Chemical Name:(S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile
CAS No.:522638-88-6
Molecular Formula:C₁₆H₂₀N₂O₃
Molecular Weight:288.346
Hs Code.:

Synonyms:(S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

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Chemical Property of (S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

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Technology Process of (S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

There total 1 articles about (S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 105104-40-3
Okahara's reagent

: 101986-32-7
(-)-N-cyanomethyl-4-phenyl-1,3-oxazolidine

: 522638-88-6
(S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

: (R)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

Guidance literature:: (-)-N-cyanomethyl-4-phenyl-1,3-oxazolidine; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

Okahara's reagent; In tetrahydrofuran; at -70 ℃; for 3h;
DOI:10.1002/ejoc.200390028

Reference yield: 84.0%

: 522638-88-6
(S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

: (2R,7S)-5-Methoxymethoxy-2-phenyl-4-oxa-1-aza-bicyclo[3.2.2]nonane-7-carbonitrile

: (S)-1-((R)-2-Methoxymethoxy-1-phenyl-ethyl)-4-oxo-piperidine-2-carbonitrile

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at -70 ℃; for 1h;
DOI:10.1002/ejoc.200390028

Reference yield:

: 522638-88-6
(S)-4-Methoxymethoxy-2-((R)-4-phenyl-oxazolidin-3-yl)-pent-4-enenitrile

: 522638-94-4
(2R,7S)-5-Methoxymethoxy-2-phenyl-4-oxa-1-aza-bicyclo[3.2.2]nonane-7-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / BF₃*Et₂O / diethyl ether / 1 h / -70 °C

2: 86 percent / K₂CO₃; H₂O₂ / methanol / 20 - 40 °C

With boron trifluoride diethyl etherate; dihydrogen peroxide; potassium carbonate; In methanol; diethyl ether;
DOI:10.1002/ejoc.200390028