TrO-PEG₅-OMs

Base Information

• Chemical Name: TrO-PEG₅-OMs
• CAS No.: 1056881-14-1
• Molecular Formula: C₃₀H₃₈O₈S
• Molecular Weight: 558.693
• Mol file: 1056881-14-1.mol

Synonyms:TrO-PEG₅-OMs

Chemical Property of TrO-PEG₅-OMs

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TrO-PEG₅-OMs

There total 2 articles about TrO-PEG₅-OMs which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pentaethylene glycol (4792-15-8) → TrO-PEG5-OMs (1056881-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / N,N-dimethyl-formamide; toluene / 22 h / 50 °C

2: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

trityl chloride (76-83-5) → TrO-PEG5-OMs (1056881-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / N,N-dimethyl-formamide; toluene / 22 h / 50 °C

2: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield: 47.0%

TrO-PEG5-OMs (1056881-14-1) + ethylamine (75-04-7,85404-22-4) → TrO-PEG5-NHEt (1147861-45-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 66h;

upstream raw materials:

Pentaethylene glycol

trityl chloride

Downstream raw materials:

3-O-MEM-6-O-TrO-PEG₅-nalbuphine

TrO-PEG₅-NHEt