ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

Base Information

• Chemical Name: ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate
• CAS No.: 1420880-43-8
• Molecular Formula: C₂₈H₂₇N₃O₆
• Molecular Weight: 505.507

Synonyms:ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

Chemical Property of ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

Chemical Property:

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Technology Process of ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate

There total 4 articles about ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))amino)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline (57598-33-1) → ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl))amino)-3-nitrobenzoate (1420880-43-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 2 h / Reflux

4.1: potassium carbonate / acetonitrile / 7 h / Reflux

With pyridine; N-Bromosuccinimide; iodine; potassium carbonate; magnesium; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; acetonitrile; 1.1: |Grignard Reaction;

DOI:10.1002/jlcr.2956

Reference yield:

2,3,5,6-tetra-[2H]-4-bromo toluene (112484-85-2) → ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl))amino)-3-nitrobenzoate (1420880-43-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 20 - 50 °C

1.2: 8 h / 20 °C

2.1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 2 h / Reflux

4.1: potassium carbonate / acetonitrile / 7 h / Reflux

With pyridine; N-Bromosuccinimide; iodine; potassium carbonate; magnesium; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; acetonitrile; 1.1: |Grignard Reaction;

DOI:10.1002/jlcr.2956

Reference yield:

4, 4-dimethyl-2-(2',3',5',6'-tetra-[2H]-4'-methyl-biphenyl-2-yl)oxazoline (1420880-35-8) → ethyl 2-(tert-butoxycarbonyl((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[2H]-methyl))amino)-3-nitrobenzoate (1420880-43-8)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate; pyridine / 3 h / 105 °C / Cooling with ice

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 2 h / Reflux

3: potassium carbonate / acetonitrile / 7 h / Reflux

With pyridine; N-Bromosuccinimide; potassium carbonate; trichlorophosphate; dibenzoyl peroxide; In tetrachloromethane; acetonitrile;

DOI:10.1002/jlcr.2956

upstream raw materials:

2,3,5,6-tetra-[²H]-4-bromo toluene

2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

4, 4-dimethyl-2-(2',3',5',6'-tetra-[²H]-4'-methyl-biphenyl-2-yl)oxazoline

2-cyano-2',3',5',6'-tetra-[²H]-4'-methyl-biphenyl

Downstream raw materials:

ethyl 2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)-3-nitrobenzoate

ethyl 3-amino-2-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl)amino)benzoate

ethyl 1-((2'-cyanobiphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo[d] imidazole-7-carboxylate

ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)(2,3,5,6-tetra-[²H]-methyl))-2-ethoxy-1H-benzo [d]imidazole-7-carboxylate

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