Technology Process of (1S,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one
There total 13 articles about (1S,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
acetone;
for 1h;
Ambient temperature;
DOI:10.1139/v97-136
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 65 percent / p-toluenesulfonic acid / tetrahydrofuran / 24 h / Heating
2: 1.) LDA / 1.) THF, from 0 deg C, 30 min, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h
3: 100 percent / H2 / 10percent Pd/C / ethyl acetate / 0.33 h / 2068.6 Torr / Ambient temperature
4: 67 percent / triflic acid / tetrahydrofuran / 14 h / 0 °C
5: 100 percent / LiAlH4 / diethyl ether / 0.17 h / Ambient temperature
6: 1.) NaH, 2.) n-Bu4NI / 1.) THF, 2.) THF, reflux, 22 h
7: 97 percent / 1M aq. HCl / acetone / 1 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethyl acetate; acetone;
DOI:10.1139/v97-136
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) LDA / 1.) THF, from 0 deg C, 30 min, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h
2: 100 percent / H2 / 10percent Pd/C / ethyl acetate / 0.33 h / 2068.6 Torr / Ambient temperature
3: 67 percent / triflic acid / tetrahydrofuran / 14 h / 0 °C
4: 100 percent / LiAlH4 / diethyl ether / 0.17 h / Ambient temperature
5: 1.) NaH, 2.) n-Bu4NI / 1.) THF, 2.) THF, reflux, 22 h
6: 97 percent / 1M aq. HCl / acetone / 1 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; lithium diisopropyl amide;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethyl acetate; acetone;
DOI:10.1139/v97-136
![(1'S,4'aS,8'aS)-1'-(2-Benzyloxy-ethyl)-5',5',8'a-trimethyl-octahydro-spiro[[1,3]dioxolane-2,2'-naphthalene]](/Databaselist/images/loading.webp)
