(1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

Base Information

Chemical Name:(1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one
CAS No.:196805-85-3
Molecular Formula:C₂₂H₃₂O₂
Molecular Weight:328.495
Hs Code.:

Synonyms:(1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

Suppliers and Price of (1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

Chemical Property:

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Technology Process of (1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

There total 17 articles about (1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 196805-84-2
(1'R,4'aS,8'aS)-1'-(2-Benzyloxy-ethyl)-5',5',8'a-trimethyl-octahydro-spiro[[1,3]dioxolane-2,2'-naphthalene]

: 196805-85-3
(1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

Guidance literature:: With hydrogenchloride; In acetone; for 4h; Ambient temperature;
DOI:10.1139/v97-136

Reference yield: 89.0%

: 196805-79-5
(1S,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

: 196805-85-3
(1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

Guidance literature:: With sodium methylate; In tetrahydrofuran; methanol; for 22h; Heating;
DOI:10.1139/v97-136

Reference yield:

: 123298-84-0
3,5,6,7,8,8a-hexahydro-5,5,8aβ-trimethylnaphthalen-2(1H)-one

: 196805-85-3
(1R,4aS,8aS)-1-(2-Benzyloxy-ethyl)-5,5,8a-trimethyl-octahydro-naphthalen-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / p-toluenesulfonic acid / tetrahydrofuran / 24 h / Heating

2: 1.) LDA / 1.) THF, from 0 deg C, 30 min, 2.) THF, a) -78 deg C, 1 h, b) 0 deg C, 1 h

3: 100 percent / H₂ / 10percent Pd/C / ethyl acetate / 0.33 h / 2068.6 Torr / Ambient temperature

4: 8 percent / triflic acid / tetrahydrofuran / 14 h / 0 °C

5: 92 percent / LiAlH₄ / diethyl ether / 0.17 h / Ambient temperature

6: 1.) NaH, 2.) n-Bu₄NI / 1.) THF, 2.) THF, reflux, 22 h

7: 96 percent / 1M aq. HCl / acetone / 4 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; acetone;
DOI:10.1139/v97-136