ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Base Information

• Chemical Name: ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate
• CAS No.: 1454288-89-1
• Molecular Formula: C₂₁H₁₈BrF₃N₂O₄S
• Molecular Weight: 531.35
• Mol file: 1454288-89-1.mol

Synonyms:ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Chemical Property of ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate

There total 6 articles about ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(5-(3’-(methylsulfonyl)-[1,1’-biphenyl]-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate (1454288-88-0) → ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate (1454288-89-1)

Guidance literature:

With N-Bromosuccinimide;

Reference yield:

para-bromoacetophenone (99-90-1) → ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate (1454288-89-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: methanol / 1 h / Reflux

3.1: caesium carbonate / acetonitrile / 6 h / 80 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

5.1: Oxone / methanol; water / 1.5 h / 20 °C

6.1: N-Bromosuccinimide

With Oxone; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

4,4,4-trifluoro-1-(4-bromophenyl)butane-1,3-dione (18931-61-8) → ethyl 2-(4-bromo-5-(3'-(methylsulfonyl)biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate (1454288-89-1)

Guidance literature:

Multi-step reaction with 5 steps

1: methanol / 1 h / Reflux

2: caesium carbonate / acetonitrile / 6 h / 80 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

4: Oxone / methanol; water / 1.5 h / 20 °C

5: N-Bromosuccinimide

With Oxone; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; caesium carbonate; In methanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

para-bromoacetophenone

4,4,4-trifluoro-1-(4-bromophenyl)butane-1,3-dione

5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazole

ethyl 2-(5-(4-bromophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetate