(E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide

Base Information

Chemical Name:(E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide
CAS No.:1620658-04-9
Molecular Formula:C₂₇H₂₅N₂O₄P
Molecular Weight:472.48
Hs Code.:

Synonyms:(E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide

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Chemical Property of (E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide

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Technology Process of (E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide

There total 5 articles about (E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1439568-51-0
2-(aminomethyl)-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

: 121-33-5,8014-42-4
vanillin

: 1620658-04-9
(E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide

Guidance literature:: With pyridinium p-toluenesulfonate; magnesium sulfate; In dichloromethane; at 23 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1002/ejoc.201400120

Reference yield:

: 628308-52-1
2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione

: 1620658-04-9
(E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 16 h / 120 °C / Inert atmosphere; Schlenk technique

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

3: hydrazine hydrate / methanol / 16 h / 90 °C / Inert atmosphere; Schlenk technique

4: pyridinium p-toluenesulfonate; magnesium sulfate / dichloromethane / 12 h / 23 °C / Schlenk technique; Inert atmosphere

With pyridinium p-toluenesulfonate; magnesium sulfate; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1002/ejoc.201400120

Reference yield:

: 1620657-78-4
2-({6-[(diphenylphosphoryl)methyl]pyridin-2-yl}methyl)isoindoline-1,3-dione

: 1620658-04-9
(E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

2: hydrazine hydrate / methanol / 16 h / 90 °C / Inert atmosphere; Schlenk technique

3: pyridinium p-toluenesulfonate; magnesium sulfate / dichloromethane / 12 h / 23 °C / Schlenk technique; Inert atmosphere

With pyridinium p-toluenesulfonate; magnesium sulfate; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1002/ejoc.201400120