2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

Base Information

• Chemical Name: 2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide
• CAS No.: 1620657-81-9
• Molecular Formula: C₂₇H₂₁N₂O₄P
• Molecular Weight: 468.448
• Mol file: 1620657-81-9.mol

Synonyms:2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

Chemical Property of 2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

There total 4 articles about 2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-({6-[(diphenylphosphoryl)methyl]pyridin-2-yl}methyl)isoindoline-1,3-dione (1620657-78-4) → 2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1620657-81-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 23 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejoc.201400120

Reference yield:

2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione (628308-52-1) → 2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1620657-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 h / 120 °C / Inert atmosphere; Schlenk technique

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1002/ejoc.201400120

Reference yield:

2,6-bis(chloromethyl)pyridine (3099-28-3) → 2-[(1,3-dioxoisoindolin-2-yl)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide (1620657-81-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 3 h / 23 °C / Inert atmosphere; Schlenk technique

2: 16 h / 120 °C / Inert atmosphere; Schlenk technique

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 23 °C / Inert atmosphere; Schlenk technique

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201400120

upstream raw materials:

2-{[6-(chloromethyl)pyridin-2-yl]methyl}isoindoline-1,3-dione

2-({6-[(diphenylphosphoryl)methyl]pyridin-2-yl}methyl)isoindoline-1,3-dione

2,6-bis(chloromethyl)pyridine

potassium phtalimide

Downstream raw materials:

2-[(benzylamino)methyl]-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide

N-({6-[(diphenylphosphoryl)methyl]-1-oxopyridin-2-yl}methyl)-4-methylbenzenesulfonamide

2-[(diphenylphosphoryl)methyl]-6-(formamidomethyl)pyridine 1-oxide

(E)-2-[(diphenylphosphoryl)methyl]-6-{[(4-hydroxy-3-methoxybenzylidene)amino]methyl}pyridine 1-oxide