tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

Base Information

Chemical Name:tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate
CAS No.:1022953-79-2
Molecular Formula:C₂₂H₂₄N₂O₅S
Molecular Weight:428.509
Hs Code.:

Synonyms:tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

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Chemical Property of tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

Chemical Property:

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Technology Process of tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

There total 5 articles about tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1022953-76-9
8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

: 24424-99-5
di-tert-butyl dicarbonate

: 1022953-79-2
tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1022953-79-2
tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 0.5 h

2.1: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 1 h / 43 °C

2.3: 0.5 h / 78 °C

3.1: dmap / dichloromethane / 1 h / 20 °C

With dmap; carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1022951-80-9
2-methyl-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

: 1022953-79-2
tert-butyl 8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 0.5 h

2.1: carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene / dichloromethane / 1 h / 43 °C

2.3: 0.5 h / 78 °C

3.1: dmap / dichloromethane / 1 h / 20 °C

With dmap; carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;