(S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride

Base Information

Chemical Name:(S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride
CAS No.:1312564-19-4
Molecular Formula:C₁₈H₁₈F₃N₃O₃*ClH
Molecular Weight:417.815
Hs Code.:

Synonyms:(S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride

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Chemical Property of (S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride

Chemical Property:

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Technology Process of (S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride

There total 7 articles about (S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1357267-37-8
(S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

: 1312564-19-4
(S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 2h;

Reference yield:

: 1131220-37-5
(S)-tert-butyl 2-(4-bromophenyl)morpholine-4-carboxylate

: 1312564-19-4
(S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 18 h / 90 °C / Inert atmosphere

2: ammonium formate; 5%-palladium/activated carbon / methanol / 2 h / 60 °C

3: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 17 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C

With 4-methyl-morpholine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5%-palladium/activated carbon; ammonium formate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; methanol; toluene;

Reference yield:

: 1260220-43-6
tert-butyl (2S)-2-(4-aminophenyl)morpholine-4-carboxylate

: 1312564-19-4
(S)-N-(4-(morpholin-2-yl)phenyl)-6-(2,2,2-trifluoroethoxy)nicotinamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / tetrahydrofuran / 17 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C

With 4-methyl-morpholine; hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane;