(S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate
CAS No.:1357267-37-8
Molecular Formula:C₂₃H₂₆F₃N₃O₅
Molecular Weight:481.472
Hs Code.:

Synonyms:(S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

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Chemical Property of (S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

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Technology Process of (S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

There total 8 articles about (S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 175204-90-7
6-(2,2,2-trifiuoroethoxy)pyridine-3-carboxylic acid

: 1260220-43-6
tert-butyl (2S)-2-(4-aminophenyl)morpholine-4-carboxylate

: 1357267-37-8
(S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

Guidance literature:: With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield: 81.0%

: 175204-90-7
6-(2,2,2-trifiuoroethoxy)pyridine-3-carboxylic acid

: 1002726-96-6
2-(4-aminophenyl)morpholine-4-carboxylic acid tert-butyl ester

: 1357267-37-8
(S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

Guidance literature:: With 4-methyl-morpholine; HBTU; In tetrahydrofuran;

Reference yield:

: 2-(4-bromophenyl)morpholine-4-carboxylate

: 1357267-37-8
(S)-tert-butyl 2-(4-(6-(2,2,2-trifluoroethoxy)nicotinamido)phenyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ethyl acetate; toluene; hexane

2: ammonium formate / palladium on charcoal / ethyl acetate; methanol

3: 4-methyl-morpholine; HBTU / tetrahydrofuran

With 4-methyl-morpholine; HBTU; ammonium formate; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on charcoal; In tetrahydrofuran; methanol; hexane; ethyl acetate; toluene;