tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate
CAS No.:240420-41-1
Molecular Formula:C₂₃H₃₆N₂O₅
Molecular Weight:420.549
Hs Code.:

Synonyms:tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

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Chemical Property of tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

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Technology Process of tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

There total 1 articles about tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 115378-31-9
tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate

: 161117-84-6
tert-butyl 2-iodophenylcarbamate

: 240420-41-1
tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 20 ℃; for 2h;

tert-butyl 2-iodophenylcarbamate; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0040-4039(99)00997-1

Reference yield:

: 240420-41-1
tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: 2-tert-butoxycarbonylamino-4-(2-tert-butoxycarbonylamino-phenyl)-butyric acid

Guidance literature:: With Jones' oxidant;
DOI:10.1016/S0040-4039(99)00997-1

Reference yield:

: 240420-41-1
tert-butyl (4R)-4-(2-{2-[(tert-butoxycarbonyl)amino]phenyl}ethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

: methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-[2-(tert-butoxycarbonylamino)phenyl]butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: Jones reagent / acetone / 0 - 20 °C

2: 27 mg / ethyl acetate; diethyl ether / 0.5 h / 0 °C

With jones reagent; In diethyl ether; ethyl acetate; acetone; 1: Jones oxidation-cleavage;
DOI:10.1021/jo010865a