Technology Process of C27H48O6Si
There total 10 articles about C27H48O6Si which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
propionaldehyde;
With
samarium diiodide;
In
tetrahydrofuran;
at -30 ℃;
for 0.166667h;
C24H42O5Si;
In
tetrahydrofuran;
at -30 ℃;
for 2h;
diastereoselective reaction;
DOI:10.1021/ol400280b
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
2.1: sodium iodide / acetone / 4 h / 60 °C
3.1: tetrahydrofuran; pentane; N,N,N,N,N,N-hexamethylphosphoric triamide / 1.5 h / -78 °C
3.2: 3.5 h / -78 °C
4.1: iodine; sodium hydrogencarbonate / tetrahydrofuran; water / 1.17 h / 0 - 20 °C
5.1: (+)-diisopinocampheylborane trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane; hexane / 3.5 h / -78 - -30 °C
5.2: 13 h / -78 - -20 °C
5.3: 2.5 h / 0 - 20 °C
6.1: samarium diiodide / tetrahydrofuran / 0.17 h / -30 °C
6.2: 2 h / -30 °C
With
samarium diiodide; iodine; sodium hydrogencarbonate; (+)-diisopinocampheylborane trifluoromethanesulfonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; acetone; pentane;
6.1: |Evans Aldol Reaction / 6.2: |Evans Aldol Reaction;
DOI:10.1021/ol400280b
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium iodide / acetone / 4 h / 60 °C
2.1: tetrahydrofuran; pentane; N,N,N,N,N,N-hexamethylphosphoric triamide / 1.5 h / -78 °C
2.2: 3.5 h / -78 °C
3.1: iodine; sodium hydrogencarbonate / tetrahydrofuran; water / 1.17 h / 0 - 20 °C
4.1: (+)-diisopinocampheylborane trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane; hexane / 3.5 h / -78 - -30 °C
4.2: 13 h / -78 - -20 °C
4.3: 2.5 h / 0 - 20 °C
5.1: samarium diiodide / tetrahydrofuran / 0.17 h / -30 °C
5.2: 2 h / -30 °C
With
samarium diiodide; iodine; sodium hydrogencarbonate; (+)-diisopinocampheylborane trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; sodium iodide;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; acetone; pentane;
5.1: |Evans Aldol Reaction / 5.2: |Evans Aldol Reaction;
DOI:10.1021/ol400280b