2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide

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Chemical Name:2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide
CAS No.:1246182-34-2
Molecular Formula:C₃₉H₃₉ClN₄O₅
Molecular Weight:679.215
Hs Code.:

Synonyms:2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide

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Chemical Property of 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide

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Technology Process of 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide

There total 3 articles about 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1246182-30-8
2-(6-aminohexyl)-6-(N,N-dimethylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 1246182-34-2
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1007/s00706-010-0337-x

Reference yield:

: 81-86-7
4-bromo-1,8-naphthalenedicarboxylic anhydride

: 1246182-34-2
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate / N,N-dimethyl-formamide / 1.5 h / Reflux

2: ethanol / 1.5 h / Inert atmosphere; Reflux

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 48 h / 20 °C / Inert atmosphere

With dmap; copper(ll) sulfate pentahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1007/s00706-010-0337-x

Reference yield:

: 77976-79-5
4-(N,N-dimethylamino)-1,8-naphthalic anhydride

: 1246182-34-2
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-{6-[6-(dimethylamino)-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl]hexyl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 1.5 h / Inert atmosphere; Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 48 h / 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; chloroform;
DOI:10.1007/s00706-010-0337-x