3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile

Base Information

Chemical Name:3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile
CAS No.:1289206-89-8
Molecular Formula:C₁₈H₁₄F₃N₃O₂
Molecular Weight:361.323
Hs Code.:

Synonyms:3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile

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Chemical Property of 3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile

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Technology Process of 3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile

There total 9 articles about 3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 680-15-9
2,2-difluoro-2-(fluorosulfonyl)acetate

: 1289206-81-0
5-bromo-3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile

: 1289206-89-8
3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile

Guidance literature:: copper(l) iodide; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;

Reference yield:

: 104-47-2
p-methoxybenzylnitrile

: 1289206-89-8
3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride; ethanol / diethyl ether; mineral oil / 20 °C

2.1: sodium acetate / water; methanol / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 20 °C

5.1: diiodomethane; isopentyl nitrite / acetonitrile / 1 h / 50 °C

6.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.5 h / 150 °C / Microwave irradiation

7.1: N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C

8.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

9.1: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With N-Bromosuccinimide; diiodomethane; ethanol; sodium acetate; boron tribromide; sodium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; isopentyl nitrite; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1289206-79-6
3-(3,5-dimethylisoxazol-4-yl)-4-(4-methoxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile

: 1289206-89-8
3-(3,5-dimethylisoxazol-4-yl)-4-(4-hydroxyphenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C

2: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

3: copper(l) iodide / N,N-dimethyl-formamide / 110 °C / Inert atmosphere

With N-Bromosuccinimide; boron tribromide; copper(l) iodide; In dichloromethane; N,N-dimethyl-formamide;